研究專長 (Research Specialties)

生理學 (Physiology)、藥理學 (Pharmacology)、細胞生物學 (Cell Biology)、皮膚科學 (Dermatology)、訊息傳遞 (Information Transmission)

研究概要 (Research Summary)

本研究室主要以天然物對氧化壓力及發炎性疾病之病理及藥理機轉作探討。本實驗團隊具備豐富的細胞篩選研究經驗與能力，擅長運用不同細胞株以增進皮膚、眼睛及腎臟疾病的健康，應用來自天然產物(如精油、多酚、胜肽及奈米/微脂體藥物)上。本研究計畫書與相關主題都以衛福部與國科會與長庚醫院相關計畫合作。 (Our laboratory primarily investigates the pathological and pharmacological mechanisms of natural products on oxidative stress and inflammatory diseases. Our experimental team possesses extensive experience and capabilities in cell screening research, adept at utilizing various cell lines to promote the health of the skin, eyes, and kidneys, with applications based on natural products (such as essential oils, polyphenols, peptides, and nano/liposomal drugs). All research proposals and related topics are collaborations with the Ministry of Health and Welfare, the National Science and Technology Council, and Chang Gung Memorial Hospital.)

研究方向 (Research Directions)

1. 評估天然物/中草藥對皮膚美白、抗皺、抗老化及抗氧化活性分析 (Evaluating the whitening, anti-wrinkle, anti-aging, and antioxidant activities of natural products/herbal medicines for skin analysis)
2. 探討天然藥物/中草藥改善皮膚炎及其機轉 (Investigating the improvement of dermatitis by natural medicines/herbal medicines and their mechanisms)
3. 探討天然藥物/中草藥減緩慢性腎病進程及其機轉 (Investigating the alleviation of chronic kidney disease progression by natural medicines/herbal medicines and their mechanisms)
4. 探討奈米/微脂體包載天然物對於皮膚炎和慢性腎病的改善 (Investigating the improvement of dermatitis and chronic kidney disease by nano/liposome-encapsulated natural products)

執行中計畫 (Ongoing Programs)

1. 長庚醫院 (Chang Gung Memorial Hospital) (2023-2024)，探討苦瓜葫蘆烷型三萜類化合物減緩慢性腎病纖維化進程 (Investigating cucurbitane-type triterpenoids from bitter gourd to mitigate chronic kidney disease fibrosis progression) (2/2)。
2. 長庚醫院 (Chang Gung Memorial Hospital) (2024-2025)，(長長)中草藥重金屬與其活性成分對泌尿上皮癌輔助治療之評估 (Evaluation of heavy metals in Chinese herbal medicine and their active components for adjuvant therapy of urothelial carcinoma) (2年 - 2 years)。
3. 長庚科技大學 (Chang Gung University of Science and Technology) (2024-2025)，探討蛇葡萄素對皮膚細胞在氧化壓力下的保護效果及其機制 (Investigating the protective effects of ampelopsin on skin cells under oxidative stress and its mechanisms)。

論文著作 (Publications)：2019-迄今 (2019-present)

1. Chen-Ni Wang^†, Ying-An Tsai^†, Ching-Yi Cheng*, Cheng-An Lin* (2023, Jun). Exploring the Potential Efficacy of Fluorescent Gold Nanoclusters on the Skin. Chang Gung Journal of Science,38, 49-58.
2. Ching-Yi Cheng^†, Yu-Hsu Chen^†, Thi Thuy Tien Vo, Ying Chui Hong, Ching-Shuen Wang, Quang Canh Vo, Han-Chin Chou, Ting-Wei Huang, I-Ta Lee* (2022, May). CORM-2 prevents human gingival fibroblasts from lipoteichoic acid-induced VCAM-1 and ICAM-1 expression by inhibiting TLR2/MyD88/TRAF6/PI3K/Akt/ROS/NF-κB signaling pathway. Biochemical Pharmacology 201, 115099.
3. Shu-Ju Wu, Wen-Chung Huang, Ching-Yi Cheng, Meng-Chun Wang, Shu-Chen Cheng*, Chian-Jiun Liou* (2022, April). Fisetin suppresses the inflammatory response and oxidative stress in bronchial epithelial cells. Nutrients, 14, 1841.
4. Ta Lee^†, Horng-Chyuan Lin^†, Tse-Hung Huang, Chi-Nan Tseng, Hao-Tsa Cheng, Wen-Chung Huang and Ching-Yi Cheng* (2022, April). Anti-Inflammatory Effect of Resveratrol Derivatives via the Downregulation of Oxidative-Stress-Dependent and c-Src Transactivation EGFR Pathways on Rat Mesangial Cells. Antioxidants, 2022, 11, 835; doi: 10.3390/antiox11050835.
5. Ming-Ming Tsai^†, Horng-Chyuan Lin^†, Ming-Chin Yu, Wan-Jung Lin, Mei-Yi Chu, Ching-Ching Tsai and Ching-Yi Cheng* (2021, October). Anticancer Effects of Helminthostachys zeylanica Ethyl acetate Extracts on Human Gastric Cancer Cells Through Downregulation of the TNF-α-activated COX-2–cPLA2–PGE2 Pathway. Journal of cancer, 12(23):7052-7068.
6. Yuan-Chieh Yeh, Chin-Chang Chen, Ching-Yi Cheng, Hsin-Ning Chang, and Tse-Hung Huan. (2021, May). The Beneficial Effects of Moxibustion on Overweight Adolescent Girls. Evidence-Based Complementary and Alternative Medicine, 2021, 1943181.
7. Ching-Yi Cheng, Thi Thuy Tien Vo, Wei-Ning Lin, Hsiang-Wei Huang, Chu-Chun Chuang, Pei-Ming Chu, I-Ta Lee* (2020, Sep). Nrf2/HO-1 Partially Regulates Cytoprotective Effects of Carbon Monoxide Against Urban Particulate Matter-Induced Inflammatory Responses in Oral Keratinocytes. Cytokine, 133, 155185.
8. Ching-Yi Cheng, Yin-Ku Lin, Shih-Chun Yang, Ahmed Alalaiwe, Chia-Jung Lin, Chwan-Fwu Lin*, Jia-You Fang* (2020, Jul). Percutaneous Absorption of Resveratrol and Its Oligomers to Relieve Psoriasiform Lesions: In Silico, In Vitro And In Vivo Evaluations. International Journal of Pharmaceutics, 585, 119507.
9. Ching-Yi Cheng*, Ashanul Haque*, Ming-Fa Hsieh*, Syed Imran Hassan, Md. Serajul Haque Faizi, Necmi Dege and Muhammad S. Khan (2020, May). 1,4-Disubstituted 1H-1,2,3-Triazoles for Renal Diseases: Studies of Viability, Anti-Inflammatory, and Antioxidant Activities. International Journal of Molecular Sciences, 21, 3823; doi:10.3390.
10. Wan-Jung Lin^†, Yi-Chieh Lee^†, Ming-Fa Hsieh*, Ching-Yi Cheng* (2019, Jun). Preparation and Evaluation of Liposomal Puerarin for Skin Damage Caused by Ultraviolet Radiation. Chang Gung Journal of Science,30, 37-48.
11. Shu-Chen Cheng, Wen-Chung Huang, Jong-Hwei S. Pang, Yi-Hong Wu* and Ching-Yi Cheng* (2019, Jun). Quercetin Inhibits the Production of IL-1β-Induced Inflammatory Cytokines and Chemokines in ARPE-19 Cells via the MAPK and NF-κB Signaling Pathways. International Journal of Molecular Sciences, 20, 2957; doi:10.3390.
12. Shu-Chen Cheng^†, Yi-Hong Wu^†, Wen-Chung Huang, Jong-Hwei S. Pang, Tse-Hung Huang, Ching-Yi Cheng* (2019, Apr). Anti-Inflammatory Property of Quercetin Through Downregulation of ICAM-1 and MMP-9 in TNF-α-Activated Retinal Pigment Epithelial Cells. Cytokine, 116:48-60.
13. I-Ta Lee, Chwan-Fwu Lin, Yu-Ling Huang, Kowit-Yu Chong, Ming-Fa Hsieh, Tse-Hung Huang, Ching-Yi Cheng* (2019, Jan). Protective Mechanisms of Resveratrol Derivatives Against TNF-Alpha-Induced Inflammatory Responses in Rat Mesangial Cells. Cytokine, 113:380-392.

生活剪影 (Laboratory Activities Snapshots)