職稱 (Job Title)：
長庚科技大學 助理教授 (Assistant Professor, Chang Gung University of Science and Technology)
主要學歷 (Education) ：
馬來西亞沙巴大學 熱帶生物學與保育研究所 博士 2018 (Ph.D., Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, 2018).
西澳大利亞大學 分子科學學院 訪問學者 2018-2019 (Visiting Fellow, School of Molecular Sciences, The University of Western Australia 2018-2019).
北海道大學 環境科學研究生院 JSPS博士後研究員 2019-2021 (JSPS Postdoctoral Fellow, Graduate School of Environmental Science, Hokkaido University 2019-2021).
新加坡國立大學 藥學系 博士後研究員 2021-2023 (Postdoctoral Researcher, Department of Pharmacy, National University of Singapore 2021-2023).
拉脫維亞有機合成研究所 天然產物研究組 首席研究員 2023-2026 (PI, Natural Products Research Group, Latvian Institute of Organic Synthesis 2023-2026).
分機號碼 (Office Telephone No.)：5100
電子郵件帳號 (Email Address)：csphan@mail.cgust.edu.tw
實驗室網站：(Laboratory Website): https://sites.google.com/view/phanlab/
研究專長 (Research Specialties)
天然產物 (Natural Products)、生物合成 (Biosynthesis)、酵素學 (Enzymology)
研究概要 (Research Summary)
我們主要關注微生物中的生物活性分子和酶，並利用它們來應對人類健康和環境永續性的挑戰，這包括對其結構、生物合成和生物活性的基本了解。(Our primary interest concerns the bioactive molecules and enzymes in microbes, repurposing them to address challenges in human health and environmental sustainability, which includes a fundamental understanding of their structures, biosynthesis, and bioactivities.)
研究方向 (Research Directions)
(1)天然產物發現：為了發現與人類健康相關的微生物天然產物，我們使用基於質譜的檢測、基於色譜的分離和基於核磁共振的表徵等技術。(Natural products discovery: To discover microbial natural products that are relevant to human health, we use techniques such as mass spectrometry-based detection, chromatography-based isolation and NMR-based characterization.)
(2) 將化學與基因聯繫起來：為了更好地了解自然界如何製造分子，我們對已鑑定的天然產物進行體內和/或體外生物合成途徑重建。(Connecting chemistry back to genes: To better understanding how nature makes molecules, we perform in vivo and/or in vitro biosynthetic pathway reconstitution of identified natural products.)
(3) 受演化啟發的探索：為了對編碼天然產物的蛋白質進行基因組挖掘，我們使用生物資訊工具（如序列相似性網絡和系統發育樹）來建構、視覺化和分析蛋白質序列。(Evolution-inspired exploration: To perform genome mining for proteins encoding natural products, we use bioinformatic tools such as sequence similarity networks and phylogenetic trees to construct, visualize and analyze protein sequences.)
(4) 酵素學：為了研究酵素的結構、底物範圍和活性位點，我們使用 AlphaFold 蛋白質結構預測、體外表徵和定點突變。(Enzymology: To study the structure, substrate scope and active site of enzymes, we use AlphaFold protein structure prediction, in vitro characterization and site-directed mutagenesis.)
學會或專業認證或得獎事蹟 (Societies, Professional Certifications, or Awards)
- 2026: Young Investigator Workshop - European Chemical Society, EU. (Nominated, selected but self-declined)
- 2025: Emerging Investigator - RSC Chemical Biology, UK.
- 2024: D. John Faulkner Award - American Society of Pharmacognosy, USA.
- 2019: JSPS Postdoc Fellowship Award - Japan Society for the Promotion of Science, Japan.
- 2018: Best PhD Thesis Award - Natural Products Society, Malaysia.
- 2018: Best PhD Thesis Award - UMS, Malaysia.
重要論文著作 (Key publications)
- Haedar J. R.,† Khan A. H.,† Gullick J., Hansen M. H., Coe L. J., De Voss J. J., Romanuks V., Smits G., Donadio S., Cryle M. J., Phan C.-S.* P450 cyptide synthase AscB catalyzes fused cyclophane at the YxWxH motif on the precursor peptides. Org. Lett. 2026, 28, 5966-5971.
- Haedar J. R.,† Kumari G. S.,† Kiselov V., Romanuks V., Smits G., Donadio S., Phan C.-S.* P450 cyptide synthase KwwB catalyzes Trp-C5–Trp-N1 cross-linking and accepts diverse precursor peptides. Org. Lett. 2026, 28, 433-437.
- Khan A. H., Haedar J. R., Kiselov V., Romanuks V., Smits G., Donadio S., Phan C.-S.* P450 biarylitide synthase ShyB catalyzes cross-link between His-C2 and Tyr-O4 on the precursor peptide. Org. Lett. 2025, 27, 5715-5719.
- Khan A. H.,† Haedar J. R.,† Kiselov V., Romanuks V., Smits G., Donadio S., Phan C.-S.* Radical SAM enzyme WprB catalyzes uniform cross-link topology between Trp-C5 and Arg-Cg on the precursor peptide. ACS Chem. Biol. 2025, 20, 259-265.
- Phan C.-S., Morinaka B. I. Sequence-function space of radical SAM cyclophane synthases reveal conserved active site residues that influence substrate specificity. RSC Chem. Biol. 2024, 5, 1195-1200.
- Phan, C.-S.,† Matsuda, K.,† Balloo, N., Fujita, K., Wakimoto, T., Okino, T. Argicyclamides A-C unveil enzymatic basis for guanidine bis-prenylation. J. Am. Chem. Soc. 2021, 143, 10083-10087.