研究專長

藥物開發與分析、中西藥物交互作用、代謝質體學、藥物動力學

研究概要

運用現代新興科技與技術在藥物、食品與化妝品的分析、開發與應用。

研究方向

1. 藥物、食品及化妝品中成分的分析方法開發平台建置
2. 中西藥物交互作用
3. 非酒精性脂肪肝的代謝體研究

最近研究主題

1. 海產類重金屬之分析方法開發與平台建置
2. 涉及抗癌藥 Cisplatin 之腎毒性的運送蛋白的中西藥物交互作用
3. 天然物對於治療非酒精性脂肪肝的代謝體研究

論文著作

1. Ming-Huei Cheng, Chun-Hui Chiuc, Chi-Tsung Chen, Hsu-Huan Choue, Li-Heng Pao, Gwo-Hwa Wan. Sources and components of volatile organic compounds in breast surgery operating rooms. Ecotoxicology and Environmental Safety, 209, (2021) 111855. https://doi.org/10.1016/j.ecoenv.2020.111855
2. Jung Chao, Hao-Yuan Cheng, Ming-Ling Chang, Shyh-Shyun Huang, Jiunn-Wang Liao, Yung-Chi Cheng, Wen-Huang Peng*, Li-Heng Pao*. Gallic Acid Ameliorated Impaired Lipid Homeostasis in a Mouse Model of High-Fat Diet- and Streptozotocin-Induced NAFLD and Diabetes through Improvement of β-oxidation and Ketogenesis. Frontiers in Pharmacology. 11:606759. (12 February 2021). https://doi.org/10.3389/fphar.2020.606759.
3. Chun-Hui Chiu, Chi-Tsung Chen, Ming-Huei Cheng, Li-Heng Pao, Chi Wang, Gwo-Hwa Wan. Use of urinary hippuric acid and o-/p-/m-methyl hippuric acid to evaluate surgical smoke exposure in operating room healthcare personnel. Ecotoxicology and Environmental Safety. April 07, 217 (2021) 112231. https://doi.org/10.1016/j.ecoenv.2021.112231
4. Shu-Hao Hsu, An-Chun Cheng, Tien-Yu Chang, Li-Heng Pao, Cheng-Huei Hsiong, Hong-Jaan Wang. Precisely adjusting the hepatic clearance of highly extracted drugs using the modified well-stirred model. Biomedicine & Pharmacotherapy. 141, September 2021, 111855. https://doi.org/10.1016/j.biopha.2021.111855.
5. Ming‑Ling Chang, Jing‑Hong Hu, Li‑Heng Pao, Ming‑Shyan Lin, Chia‑Jung Kuo, Shiang‑Chi Chen. Chun‑Ming Fan, Ming‑Yu Chang and Rong‑Nan Chien. Critical role of triglycerides for adiponectin levels in hepatitis C: a joint study of human and HCV core transgenic mice. BMC Immunology. (2021) 22:54 https://doi.org/10.1186/s12865-021-00445-5
6. Heng Lee, Rong-Nan Chien, Li-Heng Pao, Chia-Jung Kuo, Po-Han Huang and Ming-Ling Chang. Decoupled Glucose and Lipid Metabolic Recovery after Viral Clearance in Direct-Acting Antiviral-Treated HCV Patients: A 3-Year Prospective Cohort Study. Cells 2021, 10, 2934. https://doi.org/10.3390/cells10112934
7. Jung Chao, Ting-Yang Chen, Li-Heng Pao, Jeng-Shyan Deng, Yung-Chi Cheng, Shan-Yu Su* and Shyh-Shyun Huang. Ethnobotanical Survey on Bitter Tea in Taiwan. Frontiers in Pharmacology. 13:816029. https://doi.org/10.3389/fphar.2022.816029
8. Yu-Ting Kao, Shu-Fen Wang, Meng-Hsiu Wu, Shwu-Huey Her, Yi-Hsuan Yang, Chung-Hsien Lee, Hsiao-Feng Lee, An-Rong Leea,, Li-Chien Chang *, and Li-Heng Pao*. A substructure-based screening approach to uncover N-nitrosamines in drug substances. Journal of Food and Drug Analysis, 2022;30:150-162. https://doi.org/10.38212/2224-6614.3400
9. Yu-Tsung Lee^+,Li-Heng Pao⁺, Chi-Yuan Chen, Sui-Qing Huang, Alaganandam Kumaran, Jong-Ho Chyuan, and Chun-Hui Chiu. (+: equal contribution). Microwave- and Ultrasound-Assisted Extraction of Cucurbitane-Type Triterpenoids from Momordica Charantia L. Cultivars and Their Antiproliferative Effect on SAS Human Oral Cancer Cells. Foods. 2022, 11, 5. https://doi.org/10.3390/foods11050729
10. Ming-Ling Chang, Jur-Shan Chen, Ya-Hui Chuang, Li-Heng Pao, Ting-Shu Wu, Shiang-Chi Chen, Ming-Yu Chang and Rong-Nan Chien. Evolution of Cryoglobulinemia in Direct-Acting Antiviral-Treated Asian Hepatitis C Patients With Sustained Virological Responses: A 4-Year Prospective Cohort Study. Frontiers in Immunology, 08 March 2022, 13, https://doi.org/10.3389/fimmu.2022.823160
11. Tien-Yu Chang, Hong-Jaan Wang, Shu-Hao Hsu, Ming-Ling Chang, Li-Ting Kao, Li-Heng Pao*. Evidence of the need for modified well-stirred model in vitro to in vivo extrapolation. European Journal of Pharmaceutical Sciences, Volume 177, 1 October 2022, 106268. https://doi.org/10.1016/j.ejps.2022.106268
12. Yu-Tsung Lee, Sui-Qing Huang , Ching-Hao Lin, Li-Heng Pao* and Chun-Hui Chiu. Quantification of Gut Microbiota Dysbiosis-Related Organic Acids in Human Urine Using LC-MS/MS. Molecules 2022, 27, 5363. https://doi.org/10.3390/molecules27175363

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