黃聰龍 特聘教授兼任副校長

黃聰龍 (Hwang, Tsong-Long)

職稱 (Job Title)：
長庚科技大學 副校長 (Vice President, Chang Gung University of Science and Technology)
長庚科技大學健康產業科技研究所 特聘教授 (Distinguished Professor, College of Human Ecology, Chang Gung University of Science and Technology)

主要學歷 (Education) ：臺灣大學藥理學研究所 博士 (Ph.D., Institute of Pharmacology, National Taiwan University)

分機號碼 (Office Telephone No.)：5510

電子郵件帳號 (Email Address)：htl@mail.cgust.edu.tw

ORCID：https://orcid.org/0000-0002-5780-3977 (開啟新視窗)

研究室 (Laboratory)：發炎藥理學研究室 (Cellular Pharmacology Laboratory)

研究室成員 (Laboratory Members)：博士後研究員2名 (2 Postdoctoral Fellows)、專任研究助理3名 (3 Full-time Research Assistants)、博士生4名 (4 Doctoral Students)、碩士生7名 (7 Master's Students)

研究專長 (Research Interests)

發炎免疫藥理學 (Inflammatory Pharmacology)、天然物藥學 (Natural Medicine)、分子訊號傳遞 (Molecular Signaling)、藥物研發 (Drug Discovery)、藥妝和保健產品開發 (Cosmetic and Healthcare Product Development)

最近研究主題 (Recent Research Topics)

一、研究計畫 (Research Projects)

  1. 開發臺灣蘭科植物作為改善發炎代謝失調的功能性食品 (Development of Taiwanese Orchidaceae as Functional Foods to Improve Inflammatory Metabolic Disorders)
  2. 研究和開發cAMP 提升劑治療嗜中性白血球發炎疾病 (Research and Development of cAMP Enhancers for Treating Neutrophilic Inflammatory Diseases)
  3. (長長科)整合型基於傳統中藥配方尋找標靶嗜中性白血球發炎的關鍵藥材:治療急性呼吸窘迫症及腫瘤之總計畫 ((CGUST) Integrated Project on Identifying Key Medicinal Materials Targeting Neutrophilic Inflammation Based on Traditional Chinese Medicine Formulas: Overall Project for Treating Acute Respiratory Distress Syndrome and Tumors)
  4. 探討錫蘭七指蕨之Ugonins化合物調控人類嗜中性白血球發炎反應的分子機制 (Investigating the Molecular Mechanism of Ugonins Compounds from *Angiopteris evecta* in Regulating Human Neutrophilic Inflammatory Responses)
  5. 整合型系統性探討金銀花(Lonicera japonica)於炎症相關病變之治療活性與解開其作用機轉之謎之總計畫 (Integrated Systematic Investigation of the Therapeutic Activity of Honeysuckle (Lonicera japonica) in Inflammation-Related Lesions and Elucidating its Mechanism of Action: Overall Project)

二、產學合作案 (Industry-Academia Collaboration Projects)

  1. 外泌體生髮功效測試 (Exosome Hair Growth Efficacy Test)
  2. FPR1拮抗劑藥效測試 (FPR1 Antagonist Efficacy Test)
  3. GPCR體外活性鑑定與嚴重氣喘動物藥效測試 (GPCR In Vitro Activity Identification and Severe Asthma Animal Efficacy Test)
  4. ARDS和氣喘動物模型建立 (ARDS and Asthma Animal Model Establishment)
  5. 外泌體對生髮效果、發炎反應(含分子機制尋找)及傷口癒合之功效 (Efficacy of Exosomes on Hair Growth, Inflammatory Response (Including Molecular Mechanism Search), and Wound Healing)
  6. 組織培養白芨CMC指標成分檢測 (Tissue Culture *Bletilla striata* CMC Marker Component Detection)
  7. 植物新藥開發：臨床前治療效果試驗 (Phytopharmaceutical Development: Pre-clinical Therapeutic Efficacy Trials)
  8. 植物性保養品的原料製程暨功能開發 (Raw Material Process and Functional Development of Plant-based Skincare Products)
  9. 3D毛囊組織生髮技術開發暨生髮原料功能篩選 (3D Hair Follicle Tissue Hair Growth Technology Development and Hair Growth Raw Material Function Screening)

學會或專業認證 (Societies or Professional Certifications)

  • Sigma Xi: The Scientific Research Honor Society
  • The American Association of Immunologists
  • The American Society of Pharmacognosy
  • The American Chemical Society
  • Society for Redox Biology and Medicine
  • Society for Free Radical Research International
  • The Japanese Society for Investigative Dermatology
  • The Pharmaceutical Society of Japan
  • 台灣自由基學會 (Society for Free Radical Research-Taiwan)
  • 台灣藥理學會 (The Pharmacological Society in Taiwan)
  • 中華民國免疫學會 (Chinese Society of Immunology)
  • 臺灣天然藥物學會 (The Natural Medicine Society of Taiwan)
  • 臺灣傳統暨替代醫學協會 (Taiwanese Association of Traditional and Complementary Medicine)
  • 臺灣研究皮膚科醫學會 (Taiwanese Society for Investigative Dermatology)
  • 台灣藥學會 (Pharmaceutical Society of Taiwan)
  • 台灣毒物學學會 (Toxicology Society of Taiwan)
  • 台灣保健食品學會 (Health Food Society of Taiwan)

專利 (Patents)

  1. Tsong-Long Hwang, Yu-Chia Chang, Kuei-Hung Lai. 9,11-secosteroids and the use of 9,11-secosteroids in preparing pharmaceutical compositions for inhibiting inflammation. US 12,274,704 B2; Date of patent: Apr. 15, 2025.
  2. 張芳榮、吳志中、陳炳宏、黃聰龍、王士維、蒲克仁、蔡逸宏。馬卡多種生物功能解碼。中華民國發明第I 874771號；專利權期間：20250301-20420516。
    Fang-Rong Chang, Chih-Chung Wu, Bing-Hung Chen, Tsong-Long Hwang, Shih-Wei Wang, Ke-Ren Pu, Yi-Hong Tsai. Maca Multiple Biological Functions Decoding. R.O.C. Patent No. I 874771; Patent Period: 20250301-20420516.
  3. 黃聰龍、陳俞利、張祐嘉。一種草藥萃取物用於製備抑制一個體感染新型冠狀病毒的醫藥組合物之用途。中華民國發明第I 865864號；專利權期間：20241211-20420406。
    Tsong-Long Hwang, Yu-Li Chen, Yu-Chia Chang. Use of a Herbal Extract for Preparing a Pharmaceutical Composition for Inhibiting Novel Coronavirus Infection in an Individual. R.O.C. Patent No. I 865864; Patent Period: 20241211-20420406.
  4. 張芳榮、吳志中、陳炳宏、黃聰龍、王士維、蒲克仁、蔡逸宏。マカ抽出物及其用途(馬卡多種生物功能解碼)。日本特許證特許第7446003號；專利權期間：20240229 -20420503。
    Fang-Rong Chang, Chih-Chung Wu, Bing-Hung Chen, Tsong-Long Hwang, Shih-Wei Wang, Ke-Ren Pu, Yi-Hong Tsai. Maca Extract and Its Uses (Maca Multiple Biological Functions Decoding). Japanese Patent No. 7446003; Patent Period: 20240229 -20420503.
  5. Tsong-Long Hwang, Ya-Xuan Wang. Methods for the treatment of diseases associated with activation of inflammasomes. US 12,023,329 B2; Date of patent: Jul. 2, 2024.
  6. 謝珮文、黃聰龍、黃鈺凌。基尖葉野牡丹根的水萃取物在對抗冠狀病毒感染上的用途。中華民國發明第I 846385號；專利權期間：20240621 -20430315。
    Pei-Wen Hsieh, Tsong-Long Hwang, Yu-Ling Huang. Use of Aqueous Extract of *Medinilla formosana* Roots for Combating Coronavirus Infection. R.O.C. Patent No. I 846385; Patent Period: 20240621 -20430315.
  7. 黃聰龍、汪依璿、張祐嘉、宋秉鈞、陳毓昕。一種第I型甲醯胜肽受體拮抗劑及其用途。中華民國發明第I 843149號；專利權期間：20240521 -20420713。
    Tsong-Long Hwang, Yi-Hsuan Wang, Yu-Chia Chang, Ping-Chun Sung, Yu-Hsin Chen. A Type I Formyl Peptide Receptor Antagonist and Its Uses. R.O.C. Patent No. I 843149; Patent Period: 20240521 -20420713.
  8. 廖聰龍、黃聰龍、張祐嘉。一種菊花萃取物及其用於製備抑制發炎反應和促進傷口癒合的醫藥組合物之用途。中華民國發明第I 842129號；專利權期間：20240511 -20421013。
    Tsong-Long Liao, Tsong-Long Hwang, Yu-Chia Chang. A Chrysanthemum Extract and Its Use for Preparing a Pharmaceutical Composition for Inhibiting Inflammation and Promoting Wound Healing. R.O.C. Patent No. I 842129; Patent Period: 20240511 -20421013.
  9. 黃聰龍、王雅萱。一種酪氨酸激酶抑製劑在製造用以治療因炎性體激活所致相關疾病的藥物中的用途。中華人民共和國ZL 2020 1 0872049.1；專利權期間：20231208 -20400826。
    Tsong-Long Hwang, Ya-Xuan Wang. Use of a Tyrosine Kinase Inhibitor in the Manufacture of a Medicament for Treating Diseases Associated with Inflammasome Activation. P.R.C. Patent No. ZL 2020 1 0872049.1; Patent Period: 20231208 -20400826.
  10. Tsong-Long Hwang, Yu-Li Chen, Yu-Chia Chang. Method for inhibiting infection of SARS-CoV-2 in a subject. US 11,839,610 B2; Date of patent: Dec. 12, 2023.
  11. 黃聰龍、陳俞利、柯麥可、薩夫拉托娃瑪賽拉、霍斯塔科娃安娜。一種化合物用於製備抑制新型冠狀病毒感染一個體的醫藥組合物之用途。中華民國發明第I 822075號；專利權期間：20231111 -20420531。
    Tsong-Long Hwang, Yu-Li Chen, Michael Korinek, Marcela Saffranova, Anna Khvastakova. Use of a Compound for Preparing a Pharmaceutical Composition for Inhibiting Novel Coronavirus Infection in an Individual. R.O.C. Patent No. I 822075; Patent Period: 20231111 -20420531.
  12. Fang-Rong Chang, Chin-Chung Wu, Bing-Hung Chen, Tsong-Long Hwang, Shih-Wei Wang, Arif Purnomo, Yi-Hong Tsai. Maca extract and use thereof. US 11,771,729 B2; Date of patent: Oct. 3, 2023.
  13. Tsong-Long Hwang, Yeh-Long Chen, Cherng-Chyi Tzeng, Chih-Hua Tseng. Neutrophil inflammation inhibitor and uses thereof. EP3876933; Date of patent: Sep. 13, 2023.
  14. 黃聰龍、陳義龍、曾誠齊、曾志華。嗜中性白血球發炎抑制劑及其用途。中華人民共和國ZL 2018 8 0099319.0；專利權期間：20230714 -20381109。
    Tsong-Long Hwang, Yeh-Long Chen, Cherng-Chyi Tzeng, Chih-Hua Tseng. Neutrophil Inflammation Inhibitor and Its Uses. P.R.C. Patent No. ZL 2018 8 0099319.0; Patent Period: 20230714 -20381109.
  15. 黃聰龍、高定一、吳天賞。好中球の活性化及び動員の異常調節に関連する疾患の治療方法 (用以治療與嗜中性白血球激活失調及趨化相關之疾病的方法)。日本特許證特許第7244121號；專利權期間：20230313 -20410423。
    Tsong-Long Hwang, Ding-Yi Kao, Tian-Shang Wu. Methods for Treating Diseases Associated with Dysregulated Neutrophil Activation and Chemotaxis. Japanese Patent No. 7244121; Patent Period: 20230313 -20410423.
  16. 黃聰龍、陳義龍、曾誠齊、曾志華。好中球性炎症抑制剤及びその使用(嗜中性白血球發炎抑制劑及其用途。日本特許證特許第7205840號；專利權期間：20230106 -20381109。
    Tsong-Long Hwang, Yeh-Long Chen, Cherng-Chyi Tzeng, Chih-Hua Tseng. Neutrophil Inflammatory Inhibitor and Its Uses. Japanese Patent No. 7205840; Patent Period: 20230106 -20381109.
  17. 黃聰龍、姜智釗、賴奎宏、汪依璿、張祐嘉。一種中草藥組合物用於製備預防或治療皮膚病癥的外用藥物的用途。中華民國發明第I 786424號；專利權期間：20221211 -20400806。
    Tsong-Long Hwang, Chih-Chao Chiang, Kuei-Hung Lai, Yi-Hsuan Wang, Yu-Chia Chang. Use of a Chinese Herbal Composition for Preparing Topical Medicaments for Preventing or Treating Skin Conditions. R.O.C. Patent No. I 786424; Patent Period: 20221211 -20400806.
  18. 黃聰龍、高定一、吳天賞。用以治療與嗜中性白血球激活失調及趨化相關之疾病的方法。中華民國發明第I 775408號；專利權期間：20220821 -20410425。
    Tsong-Long Hwang, Ding-Yi Kao, Tian-Shang Wu. Methods for Treating Diseases Associated with Dysregulated Neutrophil Activation and Chemotaxis. R.O.C. Patent No. I 775408; Patent Period: 20220821 -20410425.
  19. 黃聰龍、王雅萱。用以治療因發炎體激活所致相關疾病的方法。中華民國發мі I 769506號；專利權期間：20220701 -20400825。
    Tsong-Long Hwang, Ya-Xuan Wang. Methods for Treating Diseases Associated with Inflammasome Activation. R.O.C. Patent No. I 769506; Patent Period: 20220701 -20400825.
  20. 黃聰龍、陳柏任。利博西林用於製備治療罹患磷酸二酯酶4介導疾病的患者的醫藥組合物及用途。中華民國發明第I 769382號；專利權期間：20220701 -20390620。
    Tsong-Long Hwang, Po-Jen Chen. Ribociclib for Preparing a Pharmaceutical Composition and Its Use for Treating Patients Suffering from Phosphodiesterase 4-Mediated Diseases. R.O.C. Patent No. I 769382; Patent Period: 20220701 -20390620.
  21. 黃聰龍、陳柏任、曾馨慧。帕博西林用於製備治療罹患疾病的患者及抑制磷脂醯肌醇3-激酶的活性的醫藥組合物及用途。中華人民共和國ZL 2020 1 0078609.6；專利權期間：20220624 -20400203。
    Tsong-Long Hwang, Po-Jen Chen, Hsin-Hui Tseng. Palbociclib for Preparing a Pharmaceutical Composition and Its Use for Treating Patients Suffering from Diseases and Inhibiting Phosphatidylinositol 3-Kinase Activity. P.R.C. Patent No. ZL 2020 1 0078609.6; Patent Period: 20220624 -20400203.
  22. Tsong-Long Hwang, Po-Jen Chen. Pharmaceutical composition and use for applying ribociclib in phosphodiesterase 4-mediated disease treatment of patient and inhibition of phosphodiesterase 4 activity. US 11,351,172 B2; Date of patent: Jun. 7, 2022.
  23. 黃聰龍、陳柏任。利博西林用於製備治療罹患磷酸二酯酶4介導疾病的患者的醫藥組合物及用途。中華人民共和國ZL 2020 1 0078474.3；專利權期間：20220419 -20400203。
    Tsong-Long Hwang, Po-Jen Chen. Ribociclib for Preparing a Pharmaceutical Composition and Its Use for Treating Patients Suffering from Phosphodiesterase 4-Mediated Diseases. P.R.C. Patent No. ZL 2020 1 0078474.3; Patent Period: 20220419 -20400203.
  24. 黃聰龍、張祐嘉、賴奎宏。9,11-開環類固醇 (9,11-secosteroids) 類化合物及其用於製備抑制發炎之醫藥組合物的用途。中華民國發明第I 742793號；專利權期間：20211011 -20400806。
    Tsong-Long Hwang, Yu-Chia Chang, Kuei-Hung Lai. 9,11-Secosteroids and Their Use for Preparing Pharmaceutical Compositions for Inhibiting Inflammation. R.O.C. Patent No. I 742793; Patent Period: 20211011 -20400806.
  25. 黃聰龍、陳柏任、曾馨慧。帕博西林用於製備治療罹患疾病的患者的醫藥組合物的用途。中華民國發明第I 737999號；專利權期間：20210901 -20390528。
    Tsong-Long Hwang, Po-Jen Chen, Hsin-Hui Tseng. Palbociclib for Preparing a Pharmaceutical Composition and Its Use for Treating Patients Suffering from Diseases. R.O.C. Patent No. I 737999; Patent Period: 20210901 -20390528.
  26. 黃聰龍、蔡永豐、陳俊宇、郭亮鉾、鄭源斌、王至欣、張芳榮、吳永昌。第I型甲醯胜肽受體拮抗劑及其用途。中華人民共和國ZL 2016 1 1257556.4；專利權期間：20210326 -20361229。
    Tsong-Long Hwang, Yung-Fong Tsai, Chun-Yu Chen, Liang-Mou Kuo, Yuan-Bin Cheng, Chih-Hsin Wang, Fang-Rong Chang, Yang-Chang Wu. Type I Formyl Peptide Receptor Antagonist and Its Uses. P.R.C. Patent No. ZL 2016 1 1257556.4; Patent Period: 20210326 -20361229.
  27. 王瑞瑜、黃聰龍、呂彥禮、方嘉佑、吳佩玲、陳瑋琪、柯錇錡。一種滋潤皮膚、具有良好的抗發炎效果之組成物。中華民國發明第I 718407號；專利權期間：20210211 -20380910。
    Ruey-Yu Wang, Tsong-Long Hwang, Yann-Lii Leu, Jia-You Fang, Pei-Ling Wu, Wei-Chi Chen, Pei-Chi Ko. A Composition for Moisturizing Skin and Having Good Anti-Inflammatory Effects. R.O.C. Patent No. I 718407; Patent Period: 20210211 -20380910.
  28. Tsong-Long Hwang, Yeh-Long Chen, Cherng-Chyi Tzeng, Chih-Hua Tseng. Neutrophil inflammation inhibitor and uses thereof. US 10,654,848 B1; Date of patent: May 19, 2020.
  29. 黃聰龍、陳義龍、曾誠齊、曾志華。嗜中性白血球發炎抑制劑及其用途。中華民國發明第I 680973號；專利權期間：20200101 -20381108。
    Tsong-Long Hwang, Yeh-Long Chen, Cherng-Chyi Tzeng, Chih-Hua Tseng. Neutrophil Inflammation Inhibitor and Its Uses. R.O.C. Patent No. I 680973; Patent Period: 20200101 -20381108.
  30. 陳日榮、簡麗娥、黃聰龍、鄭凱元。化合物及其醫藥組合物、用途及萃取自枇杷葉之方法。中華民國發明第I 640505號；專利權期間：20181111 -20361219。
    Jih-Rong Chen, Li-O Jan, Tsong-Long Hwang, Kai-Yuan Cheng. Compounds, Pharmaceutical Compositions Thereof, Uses, and Methods for Extracting from Loquat Leaves. R.O.C. Patent No. I 640505; Patent Period: 20181111 -20361219.
  31. Tsong-Long Hwang, Yung-Fong Tsai, Chun-Yu Chen, Liang-Mou Kuo, Yuan-Bin Cheng, Chih-Hsin Wang, Fang-Rong Chang, Yang-Chang Wu. Formyl peptide receptor 1 antagonists and uses thereof. US 9,895,329 B1; Date of patent: Feb. 20, 2018.
  32. 黃聰龍、謝珮文、黃吟婷、洪志豪。FPR1拮抗劑的衍生物及其用途(一)。中華民國發明第I 614021號；專利權期間：20180211 -20331008。
    Tsong-Long Hwang, Pei-Wen Hsieh, Yin-Ting Huang, Chih-Hao Hung. FPR1 Antagonist Derivatives and Uses Thereof (I). R.O.C. Patent No. I 614021; Patent Period: 20180211 -20331008.
  33. 黃聰龍、蔡永豐、陳俊宇、郭亮鉾、鄭源斌、王至欣、張芳榮、吳永昌。第I型甲醯胜肽受體拮抗劑及其用途。中華人民共和國ZL 2016 1 1257556.4；專利權期間：20171201 -20361228。
    Tsong-Long Hwang, Yung-Fong Tsai, Chun-Yu Chen, Liang-Mou Kuo, Yuan-Bin Cheng, Chih-Hsin Wang, Fang-Rong Chang, Yang-Chang Wu. Type I Formyl Peptide Receptor Antagonist and Its Uses. P.R.C. Patent No. ZL 2016 1 1257556.4; Patent Period: 20171201 -20361228.
  34. 謝珮文、黃聰龍、王雯慧、王婷儀。2-胺基苯甲醛肟衍生物及其製備方法與用途。中華人民共和國ZL 2014 1 0199178.3；專利權期間：20170412 -20340511。
    Pei-Wen Hsieh, Tsong-Long Hwang, Wen-Hui Wang, Ting-Yi Wang. 2-Aminobenzaldehyde Oxime Derivatives, Their Preparation Methods and Uses. P.R.C. Patent No. ZL 2014 1 0199178.3; Patent Period: 20170412 -20340511.
  35. Tsong-Long Hwang, Pei-Wen Hsieh, Yin-Ting Huang, Chih-Hao Hung. FPR1 antagonist derivatives and use thereof. US 9,593,144 B2; Date of patent: Mar. 14, 2017.
  36. 陳金銓、呂彥禮、黃聰龍、方嘉佑、潘台龍。哺乳類SIRT1的活化劑。中華民國發明第I 556818號；專利權期間：20161111 -20350806。
    Chin-Chuan Chen, Yann-Lii Leu, Tsong-Long Hwang, Jia-You Fang, Tai-Lung Pan. Mammalian SIRT1 Activators. R.O.C. Patent No. I 556818; Patent Period: 20161111 -20350806.
  37. 黃聰龍、謝珮文、黃吟婷、洪志豪。FPR1拮抗劑的衍生物及其用途。中華民國發明第I 537251號；專利權期間：20160611 -20331008。
    Tsong-Long Hwang, Pei-Wen Hsieh, Yin-Ting Huang, Chih-Hao Hung. FPR1 Antagonist Derivatives and Uses Thereof. R.O.C. Patent No. I 537251; Patent Period: 20160611 -20331008.
  38. Pei-Wen Hsieh, Tsong-Long Hwang, Wen-Hui Wang, Ting-Yi Wang. Oxime-based compound, pharmaceutical composition containing the same and method for preparing the same. US 9,073,833 B1; Date of patent: Jul. 7, 2015.
  39. 黃聰龍、謝珮文、余黃平。苯并雜氧嗪酮衍生物，其製備方法以及包含有此等衍生物的藥學組成物。中華民國發明第I 419884號；專利權期間：20131221 -20300623。
    Tsong-Long Hwang, Pei-Wen Hsieh, Huang-Ping Yu. Benzoxazinone Derivatives, Their Preparation Methods, and Pharmaceutical Compositions Containing Such Derivatives. R.O.C. Patent No. I 419884; Patent Period: 20131221 -20300623.
  40. 宋秉鈞、白鎮豪、蘇尹帝、黃聰龍、李展榮、林美如、許志宏、方力行。白鞭珊瑚酯及其分離方法。中華民國發明第I 353355號；專利權期間：20111201 -20280611。
    Ping-Chun Sung, Chen-Hao Pai, Yin-Ti Su, Tsong-Long Hwang, Chan-Jung Li, Mei-Ru Lin, Chih-Hung Hsu, Li-Hsing Fang. Pseudopterogorgia elisabethae Esters and Their Isolation Methods. R.O.C. Patent No. I 353355; Patent Period: 20111201 -20280611.
  41. 宋秉鈞、白鎮豪、蘇尹帝、黃聰龍、郭富雯、樊同雲、李展榮。紅鞭珊瑚醇及其分離方法。中華民國發明第I 344960號；專利權期間：20110711-20280611。
    Ping-Chun Sung, Chen-Hao Pai, Yin-Ti Su, Tsong-Long Hwang, Fu-Wen Kuo, Tung-Yun Fan, Chan-Jung Li. *Gorgonia* Alcohols and Their Isolation Methods. R.O.C. Patent No. I 344960; Patent Period: 20110711-20280611.

實驗室活動剪影 (Laboratory Activities Snapshots)

  • 黃聰龍教授與學生的合影 (Professor Tsong-Long Hwang and Students)
  • 黃聰龍教授獲獎照片 (Professor Tsong-Long Hwang receiving award)
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