黃文忠 教授

黃文忠 (Wen-Chung Huang)

職稱 (Job Title)：
教授 (Professor)

主要學歷 (Education) ：博士 (Ph.D., 國立臺灣師範大學 生命科學系 National Taiwan Normal University, Department of Life Science)

分機號碼 (Office Tel No.)：5112

電子郵件帳號 (Email Address)：wchuang@mail.cgust.edu.tw

ORCID：https://orcid.org/0000-0001-7141-8971 (開啟新視窗)

研究室 (Laboratory)：健康產業科技研究所 (Graduate Institute of Health Industry Technology)

研究室成員 (Laboratory Members)：研究助理3名 (3 Research Assistants)、碩士生4名 (4 Master's Students)、大學生4名 (4 Undergraduate Students)

研究專長 (Research Specialties)

氣喘 (Asthma)、免疫 (Immunity)、肥胖 (Obesity)、非酒精性脂肪肝 (Non-alcoholic Fatty Liver Disease)

研究概要 (Research Summary)

本實驗室研究主要聚焦於肥胖、非酒精性脂肪肝及氣喘的免疫調節。實驗室團隊已成功建立肥胖和氣喘動物模型，並依據疾病相關性結合兩種動物模型，建立穩定肥胖的氣喘小鼠模型，用於探索肥胖與氣喘之間的疾病連續性。團隊擁有一個純熱細胞篩選平台，用於檢測天然植物和生物活性成分。
(Our laboratory research primarily focuses on the immunomodulation of obesity, non-alcoholic fatty liver, and asthma. The laboratory team has successfully established animal models for obesity and asthma, and based on the correlation of these diseases, has combined the two animal models to build a stable obese asthma mouse model for exploring the disease continuum between obesity and asthma. The team possesses a thermogenic cell-screening platform for detecting natural plants and biologically active ingredients.)

研究方向 (Research Directions)

  1. 天然物質調節小鼠氣喘 (Natural Substances Regulate Asthma in Mice)
  2. 天然物質改善肥胖小鼠非酒精性脂肪肝相關的代謝途徑 (Natural Substances Improve Metabolic Pathways Related to Non-alcoholic Fatty Liver in Obese Mice)
  3. 天然物質改善異位性皮膚炎小鼠的發炎和免疫機制 (Natural Substances Improve Inflammation and Immune Mechanisms in Atopic Dermatitis Mice)

進行中計畫 (Ongoing Programs)

  1. 科技部計畫：(2023-2026) 新橙皮苷，一種新型柑橘類黃酮，調節肥胖氣喘小鼠的脂肪因子、免疫細胞功能和NLRP3發炎途徑，以減少呼吸道高反應性、發炎和氧化壓力。(National Science and Technology Council Project: (2023-2026) Neohesperidin, a Novel Citrus Flavonoid, Modulates Adipokines, Immune Cell Functions, and NLRP3 Inflammatory Pathways to Reduce Respiratory Hyperresponsiveness, Inflammation, and Oxidative Stress in Obese Asthmatic Mice.)
  2. 長庚紀念醫院計畫：(2018-2022) 芝麻酚改善肥胖小鼠非酒精性脂肪肝和呼吸道高反應性並分析發炎體和免疫細胞表達的分子機制。(Chang Gung Memorial Hospital Project: (2018-2022) Sesamol Ameliorates Nonalcoholic Fatty Liver Disease and Respiratory Hyperresponsiveness in Obese Mice and Analyzes the Molecular Mechanisms of Inflammasome and Immune Cell Expression.)
  3. 長庚紀念醫院計畫：(2023-2024) 桑苷F改善小鼠非酒精性脂肪性肝炎並分析腸道菌群和肝組織調節的轉錄組學。(Chang Gung Memorial Hospital Project: (2023-2024) Investigation of Mulberroside F to Ameliorate Non-alcoholic Steatohepatitis in Mice and Analysis of the Transcriptomics of Intestinal Flora and Liver Tissue Modulation.)
  4. 長庚紀念醫院計畫：(2024-2024) 假馬齒莧苷N2改善肥胖小鼠脂肪組織、肝臟發炎、脂質代謝和胰島素阻抗並評估調節AMPK和FGF21途徑的作用。(Chang Gung Memorial Hospital Project: (2024-2024) Bacopaside N2 Ameliorates Adipose Tissue, Hepatic Inflammation, Lipid Metabolism, and Insulin Resistance in Obese Mice and Evaluates the Role of Modulating the AMPK and FGF21 Pathways.)
  5. 長庚紀念醫院計畫：(2022-2024) 金銀花活性成分改善氣喘小鼠呼吸道發炎、氧化壓力和DNA損傷的分子機制。(Chang Gung Memorial Hospital Project: (2022-2024) Molecular Mechanisms of Honeysuckle Active Ingredients Ameliorating Respiratory Inflammation, Oxidative Stress, and DNA Damage in Asthmatic Mice.)

榮譽及獎項 (Honors and Awards)

  • 108年度長庚科技大學產學合作技術研發金獎 (2019 Chang Gung University of Science and Technology Industry-Academia Collaboration Technology R&D Gold Award)
  • 108年度長庚醫療財團法人研究獎助 (2019 Chang Gung Medical Corporation Research Grant)
  • 109年度長庚醫療財團法人研究獎勵 (2020 Chang Gung Medical Corporation Research Incentive Award)
  • 110年度長庚科技大學產學合作技術研發獎 (2021 Chang Gung University of Science and Technology Industry-Academia Collaboration Technology R&D Award)
  • 110年度長庚醫療財團法人研究獎助 (2021 Chang Gung Medical Corporation Research Grant)

論文著作 (Publications)

五年內 (2018-2024) 在SCI期刊發表49篇原創論文（其中33篇為第一作者或通訊作者）。
(Published 49 original papers in SCI journals (33 as first or corresponding author) over a five-year period (2018-2024).)

代表著作 (Selected Publications)

  1. Wen-Chung Huang, Shu-Ju Wu, Kuo-Wei Yeh, Tse-Hung Huang, Chian-Jiun Liou (2024, Jan). Protective effects of myricetin on airway inflammation and oxidative stress in ovalbumin-induced asthma mice. Journal of Nutritional Biochemistry, 123, 109485. (IF: 5.6).
  2. Wen-Chung Huang, Shu-Ju Wu Feng-Wen Hsu, Li-Wen Fang, Chian-Jiun Liou (2023, Dec).Mulberroside F improves airway hyperresponsiveness and inflammation in asthmatic mice. Kaohsiung Journal of Medical Sciences, 39(12):1213-1221. (IF:3.3).
  3. Wen-Chung Huang, Shu-Ju Wu, Li-Wen Fang, Tzu-Yung Ling, Chian-Jiun Liou (2023, Jul). Phillyrin attenuates airway inflammation and Th2 cell activities in a mouse asthma model. Food and Agricultural Immunology, 34, 2231182. (IF:3.0).
  4. Wen-Chung Huang, Chian-Jiun Liou, Szu-Chuan Shen, Sindy Hu, Jane C-J Chao, Chun-Hsun Huang, Shu-Ju Wu (2022, Aug). Oleuropein attenuates inflammation and regulates immune responses in a 2,4-dinitrochlorobenzene-induced atopic dermatitis mouse model. Asian Pacific journal of allergy and immunology, doi: 10.12932/AP-200122-1309. (IF: 7.143).
  5. Wen-Chung Huang, Shu-Ju Wu, Kuo-Wei Yeh, Chian-Jiun Liou (2022, Jun). Gypenoside A from Gynostemma pentaphyllum attenuates airway inflammation and Th2 cell activities in a murine asthma Model. International journal of molecular sciences, 23(14):7699. (IF: 6.208).
  6. Chian-Jiun Liou, Shu-Ju Wu, Szu-Chuan Shen, Li-Chen Chen, Ya-Ling Chen, Wen-Chung Huang* (2022, Apr). Acacetin protects against non-alcoholic fatty liver disease by regulating lipid accumulation and inflammation in mice. International journal of molecular sciences, 23(9):4687. (IF: 6.208).
  7. Wen-Chung Huang, Chian-Jiun Liou, Szu-Chuan Shen, Sindy Hu, Chien-Yu Hsiao, Shu-Ju Wu (2022, Apr). Urolithin A inactivation of TLR3/TRIF signaling to block the NF-κB/STAT1 axis reduces inflammation and enhances antioxidant defense in Poly(I:C)-Induced RAW264.7 cells. International journal of molecular sciences, 23(9):4697. (IF: 6.208).
  8. Ming-Lung Hsu #, Wen-Chung Huang #, Yi-Rong Zhou, Sindy Hu, Chun-Hsun Huang, Shu-Ju Wu (2022, Jan). Oleuropein protects human retinal pigment epithelium cells from IL-1β-induced inflammation by blocking MAPK/NF-κB signaling pathways. Inflammation, 45, 297-307. (IF: 4.657).
  9. Wen-Chung Huang, Tse-Hung Huang, Kuo-Wei Yeh, Ya-Ling Chen, Szu-Chuan Shen, Chian-Jiun Liou (2021, Nov). Ginsenoside Rg3 ameliorates allergic airway inflammation and oxidative stress in mice. Journal of Ginseng Research, 45(6):654-664. (IF: 5.735).
  10. Wen-Chung Huang, Shu-Ju Wu, Ya-Ling Chen, Chwan-Fwu Lin, Chian-Jiun Liou (2021, Sep). Tomatidine improves pulmonary inflammation in mice with acute lung injury. Mediators of Inflammation, 2021, 4544294. (IF: 4.529).
  11. Shu-Ju Wu, Chian-Jiun Liou, Ya-Ling Chen, Shu-Chen Cheng, Wen-Chung Huang* (2021, May). Fucoxanthin ameliorates oxidative stress and airway inflammation in tracheal epithelial cells and asthmatic mice. Cells, 10(6):1311. (IF: 7.666).
  12. Shu-Ju Wu#, Wen-Chung Huang#, Ming-Chin Yu, Ya-Ling Chen, Szu-Chuan Shen, Kuo-Wei Yeh, Chian-Jiun Liou (2021, May). Tomatidine ameliorates obesity-induced nonalcoholic fatty liver disease in mice. Journal of Nutritional Biochemistry, 91:108602. (IF: 6.117).
  13. Wen-Chung Huang, Nai-Chun Ting,Yu-Ling Huang,Li-Chen Chen, Chwan-Fwu Lin, Chian-Jiun Liou (2020, Nov). Helminthostachys zeylanica water extract ameliorates airway hyperresponsiveness and eosinophil infiltration by reducing oxidative stress and Th2 cytokine production in a mouse asthma model. Mediators of Inflammation, 1702935. (IF: 4.529).
  14. Wen-Chung Huang, Chian-Jiun Liou, Szu-Chuan Shen, Sindy Hu, Chien-Yu Hsiao, Shu-Ju Wu (2020, Oct). Luteolin attenuates IL-1β-induced THP-1 adhesion to ARPE-19 cells via suppression of NF-κB and MAPK pathways. Mediators of Inflammation, 9421340. (IF: 4.529).
  15. Chian-Jiun Liou, Shu-Ju Wu, Szu-Chuan Shen, Li-Chen Chen, Ya-Ling Chen, Wen-Chung Huang* (2020, Sep). Phloretin ameliorates hepatic steatosis through regulation of lipogenesis and Sirt1/ AMPK signaling in obese mice. Cell and Bioscience, 114. (IF: 9.597).
  16. Chian-Jiun Liou, Ya-Ling Chen, Ming-Chin Yu, Kuo-Wei Yeh, Szu-Chuan Shen, Wen-Chung Huang * (2020, Apr). Sesamol alleviates airway hyperresponsiveness and oxidative stress in asthmatic mice. Antioxidants. 295. (IF: 7.675).
  17. Nai-Chun Ting#, Wen-Chung Huang#, Li-Chen Chen, Sien-Hung Yang, Ming-Ling Kuo (2019, Dec). Descurainia sophia ameliorates eosinophil infiltration and airway hyperresponsiveness by reducing Th2 cytokine production in asthmatic mice. American Journal of Chinese Medicine, 47, 1507–1522. (IF:6.005).
  18. Chian-Jiun Liou, Yi-Wen Dai,Chia-Ling Wang, Li-Wen Fang,Wen-Chung Huang* (2019, Nov). Maslinic acid protects against obesity-induced nonalcoholic fatty liver disease in mice through regulation of the Sirt1/AMPK signaling pathway. FASEB Journal, 33(11):11791-11803. (IF: 5.834).
  19. Wen-Chung Huang, Pei-Yu Gu, Li-Wen Fang, Yu-Ling Huang, Chwan-Fwu Lin, Chian-Jiun Liou (2019, Aug). Sophoraflavanone G from Sophora flavescens induces apoptosis in triple-negative breast cancer cells. Phytomedicine, 61; 152852. (IF: 6.656).
  20. Wen-Chung Huang, Chien-Yu Liu, Szu-Chuan Shen, Li-Chen Chen, Kuo-Wei Yeh, Shih-Hai Liu, Chian-Jiun Liou (2019, Jun). Protective effects of licochalcone A improve airway hyper-responsiveness and oxidative stress in a mouse model of asthma. Cells, 8; 617. (IF: 7.666).
  21. Wen-Chung Huang, Chun-Hsun Huang, Sindy Hu, Hui-Ling Peng, Shu-Ju Wu (2019, Jun). Topical spilanthol inhibits MAPK signaling and ameliorates allergic inflammation in DNCB-induced atopic dermatitis in mice. International Journal of Molecular Sciences, 20; 2490. (IF: 6.208).
  22. Chian-Jiun Liou, Yau-Ker Lee, Nai-Chun Ting, Ya-Ling Chen, Szu-Chuan Shen, Shu-Ju Wu, Wen-Chung Huang* (2019, May). Protective effects of licochalcone A ameliorates obesity and non-alcoholic fatty liver disease via promotion of the Sirt-1/AMPK pathway in mice fed a high-fat diet. Cells, 8; 447. (IF: 7.666).
  23. Wen-Chung Huang, Hui-Ling Peng, Sindy Hu, Shu-Ju Wu (2019, May). Spilanthol from traditionally used Spilanthes acmella enhances AMPK and ameliorates obesity in mice fed high-fat diet. Nutrients, 11; 991. (IF: 6.706).
  24. Wen-Chung Huang, Haiso-Han Su, Li-Wen Fang, Shu-Ju Wu, Chian-Jiun Liou (2019, Mar). Licochalcone A inhibits cellular motility by suppressing E-cadherin and MAPK signaling in breast cancer. Cells, 8; 218. (IF: 7.666).

五年內 (2018-2024) 在SCI期刊發表49篇原創論文（其中33篇為第一作者或通通訊作者）。
(Published 49 original papers in SCI journals (33 as first or corresponding author) over a five-year period (2018-2024).)

實驗室活動剪影 (Laboratory Activities Snapshots)

  • 黃文忠教授的實驗室活動剪影 (Professor Wen-Chung Huang's Lab Activities Snapshot)